A novel fusion gene PLEKHA6-NTRK3 in langerhans cell histiocytosis.

doi:10.1002/ijc.31636

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Article

A novel fusion gene PLEKHA6-NTRK3 in langerhans cell histiocytosis.

International journal of cancer - 1 Jan 2019

Cai Jiaoyang, Huang Xia, Yin Minzhi, Pan Ci, Song Lili, Zhan Zhiyan, Chen Jing, Gao Yijin, Tang Jingyan, Li Yanxin, Shen Shuhong

Abstract excerpt

Langerhans cell histiocytosis (LCH) is the most common histiocytosis with constitutive activation of the RAS-RAF-MEK-ERK (MAPKinase) cell signaling pathway. We analyzed 89 cases of BRAF and MAP2K1 mutations by Sanger sequencing, of which 18 cases showed that these two gene mutations are negative. Whole genome sequencing of suitable specimens in these negative cases revealed a translocation from the 3 intron of...

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Identifiers

PMID: 30098202
DOI: 10.1002/ijc.31636
PMCID: PMC6587734

Genes

NTRK3
PLEKHA6
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.