Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia.

doi:10.1016/j.joca.2018.07.015

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Article

Proposal of patient-specific growth plate cartilage xenograft model for FGFR3 chondrodysplasia.

Osteoarthritis and cartilage - 1 Nov 2018

Kimura T, Ozaki T, Fujita K, Yamashita A, Morioka M, Ozono K, Tsumaki N

Abstract excerpt

OBJECTIVE: FGFR3 chondrodysplasia is caused by a gain-of-function mutation of the FGFR3 gene. The disease causes abnormal growth plate cartilage and lacks effective drug treatment. We sought to establish an in vivo model for the study of FGFR3 chondrodysplasia pathology and drug testing. DESIGN: We created cartilage from human induced pluripotent stem cells (hiPSCs) and transplanted the cartilage into the...

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Identifiers

PMID: 30086379
DOI: 10.1016/j.joca.2018.07.015

Genes

FGFR3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.