Article
Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing.
Cell - 23 Aug 2018
Attig Jan, Agostini Federico, Gooding Clare, Chakrabarti Anob M, Singh Aarti, Haberman Nejc, Zagalak Julian A, Emmett Warren, Smith Christopher W J, Luscombe Nicholas M, Ule Jernej
Abstract excerpt
Long mammalian introns make it challenging for the RNA processing machinery to identify exons accurately. We find that LINE-derived sequences (LINEs) contribute to this selection by recruiting dozens of RNA-binding proteins (RBPs) to introns. This includes MATR3, which promotes binding of PTBP1 to multivalent binding sites within LINEs. Both RBPs repress splicing and 3' end processing within and around LINEs....
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