Article
Early use of donepezil against psychosis and cognitive decline in Parkinson's disease: a randomised controlled trial for 2 years.
Journal of neurology, neurosurgery, and psychiatry - 1 Dec 2018
Sawada Hideyuki, Oeda Tomoko, Kohsaka Masayuki, Umemura Atsushi, Tomita Satoshi, Park Kwiyoung, Mizoguchi Kouichi, Matsuo Hidenori, Hasegawa Kazuko, Fujimura Harutoshi, Sugiyama Hiroshi, Nakamura Michikazu, Kikuchi Seishi, Yamamoto Kenji, Fukuda Toshiaki, Ito Suminobu, Goto Masashi, Kiyohara Kosuke, Kawamura Takashi
Abstract excerpt
OBJECTIVES: Brain acetylcholine is decreased even in patients with cognitively preserved Parkinson's disease (PD). We investigated whether early and long-term use of donepezil prevents psychosis in non-demented PD patients. METHODS: A double-blinded, placebo-controlled trial was conducted. A total of 145 non-demented PD patients were randomly assigned to receive 5 mg/day donepezil (n=72) or placebo (n=73) for 96...
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