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Functional disruption in epidermal barrier enhances toxicity and accumulation of graphene oxide.

Ecotoxicology and environmental safety - 15 Nov 2018

Ding Xuecheng, Rui Qi, Wang Dayong

Abstract excerpt

In Caenorhabditis elegans, mutation of mlt-7 causes the deficits in epidermal barrier. Using the nematodes with epidermal-specific RNA interference (RNAi) knockdown of mlt-7 as a genetic tool, we found that epidermal-specific RNAi knockdown of mlt-7 resulted in a susceptibility to graphene oxide (GO) toxicity, and enhanced GO accumulation in the body. Epidermal-development related proteins of BLI-1 and IFB-1...

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PMID: 30075448
DOI: 10.1016/j.ecoenv.2018.07.102

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