Developmental programming of aging trajectory.

doi:10.1016/j.arr.2018.07.007

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Article

Developmental programming of aging trajectory.

Ageing research reviews - 1 Nov 2018

Vaiserman Alexander, Koliada Alexander, Lushchak Oleh

Abstract excerpt

There is accumulating evidence that aging phenotype and longevity may be developmentally programmed. Main mechanisms linking developmental conditions to later-life health outcomes include persistent changes in epigenetic regulation, (re)programming of major endocrine axes such as growth hormone/insulin-like growth factor axis and hypothalamic-pituitary-adrenal axis and also early-life immune maturation. Recently,...

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Identifiers

PMID: 30059788
DOI: 10.1016/j.arr.2018.07.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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