Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease.

doi:10.1038/s41598-018-29471-x

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Article

Sputum Detection of Predisposing Genetic Mutations in Women with Pulmonary Nontuberculous Mycobacterial Disease.

Scientific reports - 27 Jul 2018

Philley Julie V, Hertweck Kate L, Kannan Anbarasu, Brown-Elliott Barbara A, Wallace Richard J, Kurdowska Anna, Ndetan Harrison, Singh Karan P, Miller Edmund J, Griffith David E, Dasgupta Santanu

Abstract excerpt

Nontuberculous mycobacterial lung disease (NTM), including Mycobacterium avium complex (MAC), is a growing health problem in North America and worldwide. Little is known about the molecular alterations occurring in the tissue microenvironment during NTM pathogenesis. Utilizing next generation sequencing, we sequenced sputum and matched lymphocyte DNA in 15 MAC patients for a panel of 19 genes known to harbor...

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