Article
The RUNX1/IL-34/CSF-1R axis is an autocrinally regulated modulator of resistance to BRAF-V600E inhibition in melanoma.
JCI insight - 26 Jul 2018
Giricz Orsi, Mo Yongkai, Dahlman Kimberly B, Cotto-Rios Xiomaris M, Vardabasso Chiara, Nguyen Hoa, Matusow Bernice, Bartenstein Matthias, Polishchuk Veronika, Johnson Douglas B, Bhagat Tushar D, Shellooe Rafe, Burton Elizabeth, Tsai James, Zhang Chao, Habets Gaston, Greally John M, Yu Yiting, Kenny Paraic A, Fields Gregg B, Pradhan Kith, Stanley E Richard, Bernstein Emily, Bollag Gideon, Gavathiotis Evripidis, West Brian L, Sosman Jeffrey A, Verma Amit K
Abstract excerpt
Resistance to current therapies still impacts a significant number of melanoma patients and can be regulated by epigenetic alterations. Analysis of global cytosine methylation in a cohort of primary melanomas revealed a pattern of early demethylation associated with overexpression of oncogenic transcripts. Loss of methylation and associated overexpression of the CSF 1 receptor (CSF1R) was seen in a majority of...
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