Article
Two HLA Class II Gene Variants Are Independently Associated with Pediatric Osteosarcoma Risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Oct 2018
Zhang Chenan, Wiemels Joseph L, Hansen Helen M, Gonzalez-Maya Julio, Endicott Alyson A, de Smith Adam J, Smirnov Ivan V, Witte John S, Morimoto Libby M, Metayer Catherine, Walsh Kyle M
Abstract excerpt
Background: The genetic etiology of osteosarcoma remains poorly understood despite the publication of a genome-wide association study. Association between HLA genetic variants and risk of several cancers has been observed, but HLA variation is not well captured by standard SNP arrays.Methods: We genotyped 207 Californian pediatric osteosarcoma cases and 696 controls of European ancestry using a custom genome-wide...
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