Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function.

doi:10.1016/j.joca.2018.07.004

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Article

Activation of AMPK-SIRT3 signaling is chondroprotective by preserving mitochondrial DNA integrity and function.

Osteoarthritis and cartilage - 1 Nov 2018

Chen L-Y, Wang Y, Terkeltaub R, Liu-Bryan R

Abstract excerpt

OBJECTIVE: In osteoarthritis (OA), articular chondrocytes manifest mitochondrial damage, including mitochondrial DNA 4977-bp (mtDNA4977) deletion that impairs mitochondrial function. OA chondrocytes have decreased activity of AMPK, an energy biosensor that promotes mitochondrial biogenesis. Here, we tested if pharmacologic AMPK activation, via downstream activation of predominately mitochondrially localized...

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Identifiers

PMID: 30031925
DOI: 10.1016/j.joca.2018.07.004
PMCID: PMC6202232

Genes

SIRT3
OGG1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.