Article
Characterization of grass carp CD40 and CD154 genes and the association between their polymorphisms and resistance to grass carp reovirus.
Fish & shellfish immunology - 1 Oct 2018
Lu Xiao-Bing, Chen Ya-Xin, Cui Zheng-Wei, Zhang Xiang-Yang, Lu Long-Feng, Li Shun, Xia Xiao-Qin, Nie Pin, Zhang Yong-An
Abstract excerpt
In bony fish, CD40 and CD154 are two very important costimulatory molecules involved in T and B cell cooperation in thymus-dependent antibody production. In the current study, we identified the cDNAs of CD40 and CD154 and analyzed their genomic structures in grass carp. Quantitative real-time PCR indicated that the CD40 and CD154 were mainly expressed in immune organs. After challenge with grass carp reovirus...
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