A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for non-squamous non-small cell lung cancer with wild-type EGFR (HOT1101).

doi:10.1007/s10147-018-1318-z

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A phase II study of carboplatin, pemetrexed, and bevacizumab followed by erlotinib and bevacizumab maintenance for non-squamous non-small cell lung cancer with wild-type EGFR (HOT1101).

International journal of clinical oncology - 1 Dec 2018

Takashina Taichi, Asahina Hajime, Oizumi Satoshi, Yamada Noriyuki, Harada Masao, Takamura Kei, Yokouchi Hiroshi, Harada Toshiyuki, Honjo Osamu, Ogi Takahiro, Morikawa Naoto, Kinoshita Ichiro, Honda Ryoichi, Nakano Kosuke, Kanazawa Kenya, Amano Toraji, Dosaka-Akita Hirotoshi, Isobe Hiroshi, Nishimura Masaharu

Abstract excerpt

BACKGROUND: This study evaluated the efficacy and safety of switch maintenance erlotinib and bevacizumab after induction therapy with carboplatin/pemetrexed/bevacizumab for non-squamous non-small cell lung cancer (NSCLC) with wild-type EGFR. METHODS: Enrolled patients had treatment-naïve, advanced non-squamous NSCLC with wild-type EGFR. Carboplatin [area under the curve (AUC) 5.0], pemetrexed (500 mg/m2) and...

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PMID: 30027464
DOI: 10.1007/s10147-018-1318-z

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EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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