Article
A Virally Encoded DeSUMOylase Activity Is Required for Cytomegalovirus Reactivation from Latency.
Cell reports - 17 Jul 2018
Poole Emma L, Kew Verity G, Lau Jonathan C H, Murray Matthew J, Stamminger Thomas, Sinclair John H, Reeves Matthew B
Abstract excerpt
A subset of viral genes is required for the long-term latent infection of hematopoietic cells by human cytomegalovirus (HCMV). Here, we show that a latency-associated gene product (LUNA) promotes the disruption of cellular PML bodies during latency. Mutation and inhibitor studies reveal that LUNA encodes a deSUMOylase activity responsible for this disruption. Specifically, LUNA encodes a conserved Asp-Cys-Gly...
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