Article
Proper conditional analysis in the presence of missing data: Application to large scale meta-analysis of tobacco use phenotypes.
PLoS genetics - 1 Jul 2018
Jiang Yu, Chen Sai, McGuire Daniel, Chen Fang, Liu Mengzhen, Iacono William G, Hewitt John K, Hokanson John E, Krauter Kenneth, Laakso Markku, Li Kevin W, Lutz Sharon M, McGue Matthew, Pandit Anita, Zajac Gregory J M, Boehnke Michael, Abecasis Goncalo R, Vrieze Scott I, Zhan Xiaowei, Jiang Bibo, Liu Dajiang J
Abstract excerpt
Meta-analysis of genetic association studies increases sample size and the power for mapping complex traits. Existing methods are mostly developed for datasets without missing values, i.e. the summary association statistics are measured for all variants in contributing studies. In practice, genotype imputation is not always effective. This may be the case when targeted genotyping/sequencing assays are used or...
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