Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees.

doi:10.1161/CIRCGEN.117.002038

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Article

Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees.

Circulation. Genomic and precision medicine - 1 Jul 2018

Cowan Jason R, Kinnamon Daniel D, Morales Ana, Salyer Lorien, Nickerson Deborah A, Hershberger Ray E

Abstract excerpt

BACKGROUND: We have previously described 19 pedigrees with apparent lamin (LMNA)-related dilated cardiomyopathy (DCM) manifesting in affected family members across multiple generations. In 6 of 19 families, at least 1 individual with idiopathic DCM did not carry the family's LMNA variant. We hypothesized that additional genetic cause may underlie DCM in these families. METHODS: Affected family members underwent...

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Identifiers

PMID: 30012837
DOI: 10.1161/CIRCGEN.117.002038
PMCID: PMC6294440

Genes

LMNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.