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Article

Spastic paraparesis as the first manifestation of Machado-Joseph disease: A case report and review of the literature.

Clinical neurology and neurosurgery - 1 Sept 2018

Lin Hui-Chen, Chang Yung-Yee, Chang Kuo-Hsuan, Chen Ying-Fa, Lan Min-Yu

Abstract excerpt

Machado-Joseph disease (MJD), or spinocerebellar ataxia type 3, is characterized by remarkable clinical heterogeneity. We present a MJD family in which variable phenotypes were noted in affected members, including one presenting predominantly with spastic paraparesis. A review of the literature revealed that MJD with the initial presentation of spastic paraparesis is more frequently observed in cases of eastern...

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Source

Identifiers

PMID: 30007589
DOI: 10.1016/j.clineuro.2018.06.037

Genes

ATXN3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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