You won't believe this old test … that does cheap single-cell mutation detection.

doi:10.1002/cjp2.108

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Article

You won't believe this old test … that does cheap single-cell mutation detection.

The journal of pathology. Clinical research - 1 Jul 2018

Köbel Martin, Anglesio Michael S, Brenton James D

Abstract excerpt

Detecting mutations in single cells from cancer specimens is now a major area of translational research. In a recent article in this journal, Khalique et al validated an immunohistochemistry assay for ARID1A that reliably identifies loss of function mutations in single cells in tissue sections. This work exemplifies best practice for developing and orthogonally validating immunohistochemical assays to provide...

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PMID: 30003713
DOI: 10.1002/cjp2.108
PMCID: PMC6065114

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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