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Article

High Growth Rate of Pancreatic Ductal Adenocarcinoma in CDKN2A-p16-Leiden Mutation Carriers.

Cancer prevention research (Philadelphia, Pa.) - 1 Sept 2018

Ibrahim Isaura S, Wasser Martin N, Wu Yinghui, Inderson Akin, de Vos Tot Nederveen Cappel Wouter H, Morreau Hans, Hes Frederik J, Veenendaal Roeland A, Putter Hein, Feshtali Shirin, van Mil Anneke M, Gruis Nelleke A, Tollenaar Rob A, Bergman Wilma, Bonsing Bert A, Vasen Hans F A

Abstract excerpt

CDKN2A-p16-Leiden mutation carriers have a 20% to 25% risk of developing pancreatic ductal adenocarcinoma (PDAC). Better understanding of the natural course of PDAC might allow the surveillance protocol to be improved. The aims of the study were to evaluate the role of cystic precursor lesions in the development of PDAC and to assess the growth rate. In 2000, a surveillance program was initiated, consisting of...

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Identifiers

PMID: 29991580
DOI: 10.1158/1940-6207.CAPR-18-0035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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