Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

doi:10.1194/jlr.P085118

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Article

Omega-6 oxylipins generated by soluble epoxide hydrolase are associated with knee osteoarthritis.

Journal of lipid research - 1 Sept 2018

Valdes Ana M, Ravipati Srinivasarao, Pousinis Petros, Menni Cristina, Mangino Massimo, Abhishek Abhishek, Chapman Victoria, Barrett David A, Doherty Michael

Abstract excerpt

Omega-6 FAs are inflammatory mediators that are increased in joints with osteoarthritis (OA), but their association with OA progression is not yet well defined. To investigate the relationship between omega-6 FAs and knee OA, we measured with LC-MS the levels of 22 omega-6 lipids (arachidonic acid, linoleic acid, and 20 oxylipins) in synovial fluid (SF) from 112 knees of 102 individuals (58 with knee OA; 44...

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Identifiers

PMID: 29986999
DOI: 10.1194/jlr.P085118
PMCID: PMC6121933

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.