Use of genomic and functional analysis to characterize patients with steroid-resistant nephrotic syndrome.

doi:10.1007/s00467-018-3995-2

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Article

Use of genomic and functional analysis to characterize patients with steroid-resistant nephrotic syndrome.

Pediatric nephrology (Berlin, Germany) - 1 Oct 2018

Kitzler Thomas M, Kachurina Nadezda, Bitzan Martin M, Torban Elena, Goodyer Paul R

Abstract excerpt

BACKGROUND: Children with genetic causes of steroid-resistant nephrotic syndrome (SRNS) usually do well after renal transplantation, while some with idiopathic SRNS show recurrence due to a putative podocyte-toxic factor. Distinguishing different forms of SRNS based on clinical criteria has been difficult. The aim of our study was to test a novel approach that allows categorization of patients into clinically...

Topics

Adolescent
Adult
Cell Culture Techniques
Cell Line
Child
Child, Preschool
Drug Resistance
Female
Glucocorticoids
High-Throughput Nucleotide Sequencing
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Nephrotic Syndrome

Podocytes

Recurrence

Retrospective Studies

Young Adult

Source

Open in PubMed

Identifiers

PMID: 29982877
DOI: 10.1007/s00467-018-3995-2

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