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Article

Genetic Mutations in a Patient with Chronic Myeloid Leukemia Showing Blast Crisis 10 Years After Presentation.

Anticancer research - 1 Jul 2018

Sklarz Lisa-Madeleine, Wittke Christoph, Krohn Saskia, GROßE-Thie Christina, Junghanss Christian, Murua Escobar Hugo, Glaeser Hartmut

Abstract excerpt

Since the introduction of tyrosine kinase inhibitors (TKI), the prospects for patients with chronic myeloid leukemia (CML) have improved significantly. Herein we present the case of a patient with CML who experienced blast crisis and development of acute myeloid leukemia (AML) 10 years after presentation. The CML was characterized by the gene fusion of breakpoint cluster region BCR and tyrosine-protein kinase...

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Topics

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Share to Blast Crisis
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomes, Human, Pair 7

Share to Hematopoietic Stem Cell Transplantation

Share to In Situ Hybridization, Fluorescence

Share to Karyotyping

Share to Leukemia, Myelogenous, Chronic, BCR-ABL Positive

Share to Proto-Oncogene Mas

Source

Identifiers

PMID: 29970518
DOI: 10.21873/anticanres.12682

Genes

ABL1
BCR
MET
PTPN11

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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