Article
A single amino acid polymorphism in ABCC2 loop 1 is responsible for differential toxicity of Bacillus thuringiensis Cry1Ac toxin in different Spodoptera (Noctuidae) species.
Insect biochemistry and molecular biology - 1 Sept 2018
Liu Leilei, Chen Zuwen, Yang Yanchao, Xiao Yutao, Liu Chenxi, Ma Yuemin, Soberón Mario, Bravo Alejandra, Yang Yongbo, Liu Kaiyu
Abstract excerpt
Bacillus thuringiensis Cry toxins exert their toxicity by forming membrane pores after binding with larval midgut membrane proteins known as receptors. Spodoptera litura and Spodoptera frugiperda belong to the same genus, but S. litura is tolerant to Cry1Ac, while S. frugiperda is susceptible. The mechanism involved in the differential toxicity of Cry1Ac to these insect species is not understood. Amino acid...
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