Article
Integration of "Omics" Strategies for Biomarkers Discovery and for the Elucidation of Molecular Mechanisms Underlying Brugada Syndrome.
Proteomics. Clinical applications - 1 Nov 2018
Scumaci Domenica, Oliva Antonio, Concolino Antonio, Curcio Antonio, Fiumara Claudia Vincenza, Tammè Laura, Campuzano Oscar, Pascali Vincenzo L, Coll Monica, Iglesias Anna, Berne Paola, Casu Gavino, Olivo Erika, Ausania Francesco, Ricci Pietrantonio, Indolfi Ciro, Brugada Josep, Brugada Ramon, Cuda Giovanni
Abstract excerpt
PURPOSE: The Brugada syndrome (BrS) is a severe inherited cardiac disorder. Given the high genetic and phenotypic heterogeneity of this disease, three different "omics" approaches are integrated in a synergic way to elucidate the molecular mechanisms underlying the pathophysiology of BrS as well as for identifying reliable diagnostic/prognostic markers. EXPERIMENTAL DESIGN: The profiling of plasma Proteome and...
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