7B2 chaperone knockout in APP model mice results in reduced plaque burden.

doi:10.1038/s41598-018-28031-7

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Article

7B2 chaperone knockout in APP model mice results in reduced plaque burden.

Scientific reports - 28 Jun 2018

Jarvela Timothy S, Womack Tasha, Georgiou Polymnia, Gould Todd D, Eriksen Jason L, Lindberg Iris

Abstract excerpt

Impairment of neuronal proteostasis is a hallmark of Alzheimer's and other neurodegenerative diseases. However, the underlying molecular mechanisms leading to pathogenic protein aggregation, and the role of secretory chaperone proteins in this process, are poorly understood. We have previously shown that the neural-and endocrine-specific secretory chaperone 7B2 potently blocks in vitro fibrillation of Aβ42. To...

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PMID: 29955078
DOI: 10.1038/s41598-018-28031-7
PMCID: PMC6023903

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.