A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts.

doi:10.1074/jbc.RA118.004059

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Article

A genetic model to study O-GlcNAc cycling in immortalized mouse embryonic fibroblasts.

The Journal of biological chemistry - 31 Aug 2018

St Amand Melissa M, Bond Michelle R, Riedy Julia, Comly Marcella, Shiloach Joseph, Hanover John A

Abstract excerpt

O-GlcNAcylation is an abundant posttranslational protein modification in which the monosaccharide O-GlcNAc is added to Ser/Thr residues by O-GlcNAc transferase and removed by O-GlcNAcase. Analyses of O-GlcNAc-mediated signaling and metabolic phenomena are complicated by factors including unsatisfactory inhibitors and loss-of-function cell lines lacking identical genetic backgrounds. In this work, we generated...

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PMID: 29954943
DOI: 10.1074/jbc.RA118.004059
PMCID: PMC6120200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.