Article
Keratinocyte differentiation induces APOBEC3A, 3B, and mitochondrial DNA hypermutation.
Scientific reports - 27 Jun 2018
Wakae Kousho, Nishiyama Tomoaki, Kondo Satoru, Izuka Takashi, Que Lusheng, Chen Cong, Kase Kina, Kitamura Kouichi, Mohiuddin Md, Wang Zhe, Ahasan Md Monjurul, Nakamura Mitsuhiro, Fujiwara Hiroshi, Yoshizaki Tomokazu, Hosomochi Kazuyoshi, Tajima Atsushi, Nakahara Tomomi, Kiyono Tohru, Muramatsu Masamichi
Abstract excerpt
Mitochondrial DNA (mtDNA) mutations are found in many types of cancers and suspected to be involved in carcinogenesis, although the mechanism has not been elucidated. In this study, we report that consecutive C-to-T mutations (hypermutations), a unique feature of mutations induced by APOBECs, are found in mtDNA from cervical dysplasia and oropharyngeal cancers. In vitro, we found that APOBEC3A (A3A) and 3B (A3B)...
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