A computational approach to identify cellular heterogeneity and tissue-specific gene regulatory networks.

doi:10.1186/s12859-018-2190-6

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Article

A computational approach to identify cellular heterogeneity and tissue-specific gene regulatory networks.

BMC bioinformatics - 7 Jun 2018

Jambusaria Ankit, Klomp Jeff, Hong Zhigang, Rafii Shahin, Dai Yang, Malik Asrar B, Rehman Jalees

Abstract excerpt

BACKGROUND: The heterogeneity of cells across tissue types represents a major challenge for studying biological mechanisms as well as for therapeutic targeting of distinct tissues. Computational prediction of tissue-specific gene regulatory networks may provide important insights into the mechanisms underlying the cellular heterogeneity of cells in distinct organs and tissues. RESULTS: Using three pathway...

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Identifiers

PMID: 29940845
DOI: 10.1186/s12859-018-2190-6
PMCID: PMC6019795

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.