GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.

doi:10.1038/s41598-018-27864-6

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

GRAMD1B regulates cell migration in breast cancer cells through JAK/STAT and Akt signaling.

Scientific reports - 22 Jun 2018

Khanna Puja, Lee Joan Shuying, Sereemaspun Amornpun, Lee Haeryun, Baeg Gyeong Hun

Abstract excerpt

Dysregulated JAK/STAT signaling has been implicated in breast cancer metastasis, which is associated with high relapse risks. However, mechanisms underlying JAK/STAT signaling-mediated breast tumorigenesis are poorly understood. Here, we showed that GRAMD1B expression is upregulated on IL-6 but downregulated upon treatment with the JAK2 inhibitor AG490 in the breast cancer MDA-MB-231 cells. Notably, Gramd1b...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms
Share to Cell Movement
Share to Down-Regulation
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to Janus Kinases

Share to Proto-Oncogene Proteins c-akt

Share to STAT Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 29934528
DOI: 10.1038/s41598-018-27864-6
PMCID: PMC6015000

Genes

JAK2
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.