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Article

The Bacterial Protein CNF1 as a Potential Therapeutic Strategy against Mitochondrial Diseases: A Pilot Study.

International journal of molecular sciences - 21 Jun 2018

Fabbri Alessia, Travaglione Sara, Maroccia Zaira, Guidotti Marco, Pierri Ciro Leonardo, Primiano Guido, Servidei Serenella, Loizzo Stefano, Fiorentini Carla

Abstract excerpt

The Escherichia coli protein toxin cytotoxic necrotizing factor 1 (CNF1), which acts on the Rho GTPases that are key regulators of the actin cytoskeleton, is emerging as a potential therapeutic tool against certain neurological diseases characterized by cellular energy homeostasis impairment. In this brief communication, we show explorative results on the toxin’s effect on fibroblasts derived from a patient...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitochondrial Precursor Protein Import Complex Proteins

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Identifiers

PMID: 29933571
DOI: 10.3390/ijms19071825
PMCID: PMC6073533

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