Article
Hypoalphalipoproteinemia and BRAFV600E Mutation Are Major Predictors of Aortic Infiltration in the Erdheim-Chester Disease.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2018
Cohen-Aubart Fleur, Guerin Maryse, Poupel Lucie, Cluzel Philippe, Saint-Charles Flora, Charlotte Frédéric, Arsafi Youssef, Emile Jean-François, Frisdal Eric, Le Goff Carine, Donadieu Jean, Amoura Zahir, Lesnik Philippe, Haroche Julien, Le Goff Wilfried
Abstract excerpt
Objective- Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocytosis characterized by the infiltration of multiple tissues with lipid-laden histiocytes. Cardiovascular involvement is frequent in ECD and leads to a severe prognosis. The objective of this study was to determine whether an alteration of lipid metabolism participates in the lipid accumulation in histiocytes and the cardiovascular...
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