Article
Gestational Hypothyroxinemia Affects Its Offspring With a Reduced Suppressive Capacity Impairing the Outcome of the Experimental Autoimmune Encephalomyelitis.
Frontiers in immunology - 1 Jan 2018
Haensgen Henny, Albornoz Eduardo, Opazo María C, Bugueño Katherinne, Jara Fernández Evelyn Liliana, Binzberger Rebecca, Rivero-Castillo Tomás, Venegas Salas Luis F, Simon Felipe, Cabello-Verrugio Claudio, Elorza Alvaro A, Kalergis Alexis M, Bueno Susan M, Riedel Claudia A
Abstract excerpt
Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the...
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