Article
Novel antibody reagents for characterization of drug- and tumor microenvironment-induced changes in epithelial-mesenchymal transition and cancer stem cells.
PloS one - 1 Jan 2018
Navas Tony, Pfister Thomas D, Colantonio Simona, Aziz Amina, Dieckman Lynda, Saul Richard G, Kaczmarczyk Jan, Borgel Suzanne, Alcoser Sergio Y, Hollingshead Melinda G, Lee Young H, Bottaro Donald P, Hiltke Tara, Whiteley Gordon, Takebe Naoko, Kinders Robert J, Parchment Ralph E, Tomaszewski Joseph E, Doroshow James H
Abstract excerpt
The presence of cancer stem cells (CSCs) and the induction of epithelial-to-mesenchymal transition (EMT) in tumors are associated with tumor aggressiveness, metastasis, drug resistance, and poor prognosis, necessitating the development of reagents for unambiguous detection of CSC- and EMT-associated proteins in tumor specimens. To this end, we generated novel antibodies to EMT- and CSC-associated proteins,...
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