Article
Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
Nature - 1 Jun 2018
Yu Ruby, Wang Xiaoyi, Moazed Danesh
Abstract excerpt
Histone post-translational modifications (PTMs) are associated with epigenetic states that form the basis for cell-type-specific gene expression1,2. Once established, histone PTMs can be maintained by positive feedback involving enzymes that recognize a pre-existing histone modification and catalyse the same modification on newly deposited histones. Recent studies suggest that in wild-type cells, histone...
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