A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.

doi:10.1016/j.jmb.2018.06.017

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Article

A Proteomic Variant Approach (ProVarA) for Personalized Medicine of Inherited and Somatic Disease.

Journal of molecular biology - 14 Sept 2018

Hutt Darren M, Loguercio Salvatore, Campos Alexandre Rosa, Balch William E

Abstract excerpt

The advent of precision medicine for genetic diseases has been hampered by the large number of variants that cause familial and somatic disease, a complexity that is further confounded by the impact of genetic modifiers. To begin to understand differences in onset, progression and therapeutic response that exist among disease-causing variants, we present the proteomic variant approach (ProVarA), a proteomic...

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PMID: 29924966
DOI: 10.1016/j.jmb.2018.06.017
PMCID: PMC6097907

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.