RNAi-Based GluN3A Silencing Prevents and Reverses Disease Phenotypes Induced by Mutant huntingtin.

doi:10.1016/j.ymthe.2018.05.013

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Article

RNAi-Based GluN3A Silencing Prevents and Reverses Disease Phenotypes Induced by Mutant huntingtin.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Aug 2018

Marco Sonia, Murillo Alvaro, Pérez-Otaño Isabel

Abstract excerpt

Huntington's disease (HD) is a dominantly inherited neurodegenerative disease caused by expansion of a polyglutamine tract in the huntingtin protein. HD symptoms include severe motor, cognitive, and psychiatric impairments that result from dysfunction and later degeneration of medium-sized spiny neurons (MSNs) in the striatum. A key early pathogenic mechanism is dysregulated synaptic transmission due to enhanced...

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Identifiers

PMID: 29914757
DOI: 10.1016/j.ymthe.2018.05.013
PMCID: PMC6094357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.