The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus.

doi:10.1128/JVI.00754-18

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Article

The Influenza B Virus Hemagglutinin Head Domain Is Less Tolerant to Transposon Mutagenesis than That of the Influenza A Virus.

Journal of virology - 15 Aug 2018

Fulton Benjamin O, Sun Weina, Heaton Nicholas S, Palese Peter

Abstract excerpt

Influenza A and B viruses can continuously evade humoral immune responses by developing mutations in the globular head of the hemagglutinin (HA) that prevent antibody binding. However, the influenza B virus HA over time displays less antigenic variation despite being functionally and structurally similar to the influenza A virus HA. To determine if the influenza B virus HA is under constraints that limit its...

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Share to Antigenic Variation
Share to DNA Transposable Elements
Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 29899093
DOI: 10.1128/JVI.00754-18
PMCID: PMC6069205

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.