Article
Four-dimensional, dynamic mosaicism is a hallmark of normal human skin that permits mapping of the organization and patterning of human epidermis during terminal differentiation.
PloS one - 1 Jan 2018
Wang Yun, Masaki Taro, Khan Sikandar G, Tamura Deborah, Kuschal Christiane, Rogers Megan, DiGiovanna John J, Kraemer Kenneth H
Abstract excerpt
Recent findings of mosaicism (DNA sequence variation) challenge the dogma that each person has a stable genetic constitution. Copy number variations, point mutations and chromosome abnormalities in normal or diseased tissues have been described. We studied normal skin mosaicism of a single nucleotide polymorphism (SNP) [rs1426654, p.Thr111Ala] in SLC24A5, an ion transporter gene. This SNP is unusual in that more...
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