Article
The Mutation-Associated Neoantigen Functional Expansion of Specific T Cells (MANAFEST) Assay: A Sensitive Platform for Monitoring Antitumor Immunity.
Cancer immunology research - 1 Aug 2018
Danilova Ludmila, Anagnostou Valsamo, Caushi Justina X, Sidhom John-William, Guo Haidan, Chan Hok Yee, Suri Prerna, Tam Ada, Zhang Jiajia, Asmar Margueritta El, Marrone Kristen A, Naidoo Jarushka, Brahmer Julie R, Forde Patrick M, Baras Alexander S, Cope Leslie, Velculescu Victor E, Pardoll Drew M, Housseau Franck, Smith Kellie N
Abstract excerpt
Mutation-associated neoantigens (MANA) are a target of antitumor T-cell immunity. Sensitive, simple, and standardized assays are needed to assess the repertoire of functional MANA-specific T cells in oncology. Assays analyzing in vitro cytokine production such as ELISpot and intracellular cytokine staining have been useful but have limited sensitivity in assessing tumor-specific T-cell responses and do not...
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