Article
The promising PARP inhibitors in ovarian cancer therapy: From Olaparib to others.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2018
Chen Ying, Du Hui
Abstract excerpt
Epithelial ovarian cancer (EOC) accounts for 90% of all ovarian cancer. Initially, approaching 80% of EOC patients respond to standard therapeutic strategy, cytoreduction combining with postoperative auxiliary platinum-based chemotherapy. However, relapse is approximately inevitable because of drug-resistance for high-grade serous ovarian cancer (HGSOC). Recently, the nuclear enzyme poly (ADP-ribose) polymerase...
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