Article
Emergence of Azole-Resistant Aspergillus fumigatus from Immunocompromised Hosts in India.
Antimicrobial agents and chemotherapy - 1 Aug 2018
Dabas Yubhisha, Xess Immaculata, Bakshi Sameer, Mahapatra Manoranjan, Seth Rachna
Abstract excerpt
This prospective study shows that the rate of azole-resistant Aspergillus fumigatus (ARAF) in an immunocompromised Indian patient population with invasive aspergillosis (IA) is low, 6/706 (0.8%). This low rate supports the continued use of voriconazole as the first line of treatment. However, the ARAF isolates from India in this study exhibited three kinds of unreported cyp51A mutations, of which two were at hot...
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