Article
A Secondary Mutation in BRAF Confers Resistance to RAF Inhibition in a BRAFV600E-Mutant Brain Tumor.
Cancer discovery - 1 Sept 2018
Wang Jiawan, Yao Zhan, Jonsson Philip, Allen Amy N, Qin Alice Can Ran, Uddin Sharmeen, Dunkel Ira J, Petriccione Mary, Manova Katia, Haque Sofia, Rosenblum Marc K, Pisapia David J, Rosen Neal, Taylor Barry S, Pratilas Christine A
Abstract excerpt
BRAFV600E hyperactivates ERK and signals as a RAF inhibitor-sensitive monomer. Although RAF inhibitors can produce impressive clinical responses in patients with mutant BRAF tumors, the mechanisms of resistance to these drugs are incompletely characterized. Here, we report a complete response followed by clinical progression in a patient with a BRAFV600E-mutant brain tumor treated with dabrafenib. Whole-exome...
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