Article
Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese.
BMC medical genetics - 7 Jun 2018
Sakiyama Masayuki, Matsuo Hirotaka, Nakaoka Hirofumi, Kawamura Yusuke, Kawaguchi Makoto, Higashino Toshihide, Nakayama Akiyoshi, Akashi Airi, Ueyama Jun, Kondo Takaaki, Wakai Kenji, Sakurai Yutaka, Yamamoto Ken, Ooyama Hiroshi, Shinomiya Nariyoshi
Abstract excerpt
BACKGROUND: Gout is a common disease resulting from hyperuricemia which causes acute arthritis. A recent genome-wide association study (GWAS) of gout identified three new loci for gout in Han Chinese: regulatory factor X3 (RFX3), potassium voltage-gated channel subfamily Q member 1 (KCNQ1), and breast carcinoma amplified sequence 3 (BCAS3). The lack of any replication studies of these three loci using other...
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