Article
Marked Reduction in the Striatal Dopamine Transporter Uptake During the Early Stage of Motor Symptoms in Patients with the MAPT N279K Mutation.
Internal medicine (Tokyo, Japan) - 15 Oct 2018
Takeshige Haruka, Nakayama Sachiko, Nishioka Kenya, Li Yuanzhe, Motoi Yumiko, Hattori Nobutaka
Abstract excerpt
We herein report two patients harboring the mutation N279K in microtubule-associated protein tau (MAPT), who showed parkinsonism with a disease duration within three years from the onset, evaluated by dopamine transporter (DAT) [123I]N-ω-fluoroprophyl-2β-carbomethoxy-3β-(4-iodophenyl) tropane single-photon emission computed tomography. We performed a quantification analysis, comparing five age- and...
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