Article
A Drosophila Tumor Suppressor Gene Prevents Tonic TNF Signaling through Receptor N-Glycosylation.
Developmental cell - 4 Jun 2018
de Vreede Geert, Morrison Holly A, Houser Alexandra M, Boileau Ryan M, Andersen Ditte, Colombani Julien, Bilder David
Abstract excerpt
Drosophila tumor suppressor genes have revealed molecular pathways that control tissue growth, but mechanisms that regulate mitogenic signaling are far from understood. Here we report that the Drosophila TSG tumorous imaginal discs (tid), whose phenotypes were previously attributed to mutations in a DnaJ-like chaperone, are in fact driven by the loss of the N-linked glycosylation pathway component ALG3. tid/alg3...
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