Article
Multi-Omics Analysis Reveals a HIF Network and Hub Gene EPAS1 Associated with Lung Adenocarcinoma.
EBioMedicine - 1 Jun 2018
Wang Zhaoxi, Wei Yongyue, Zhang Ruyang, Su Li, Gogarten Stephanie M, Liu Geoffrey, Brennan Paul, Field John K, McKay James D, Lissowska Jolanta, Swiatkowska Beata, Janout Vladimir, Bolca Ciprian, Kontic Milica, Scelo Ghislaine, Zaridze David, Laurie Cathy C, Doheny Kimberly F, Pugh Elizabeth K, Marosy Beth A, Hetrick Kurt N, Xiao Xiangjun, Pikielny Claudio, Hung Rayjean J, Amos Christopher I, Lin Xihong, Christiani David C
Abstract excerpt
Recent technological advancements have permitted high-throughput measurement of the human genome, epigenome, metabolome, transcriptome, and proteome at the population level. We hypothesized that subsets of genes identified from omic studies might have closely related biological functions and thus might interact directly at the network level. Therefore, we conducted an integrative analysis of multi-omic datasets...
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