Article
The co-existence of NS5A and NS5B resistance-associated substitutions is associated with virologic failure in Hepatitis C Virus genotype 1 patients treated with sofosbuvir and ledipasvir.
PloS one - 1 Jan 2018
Mawatari Seiichi, Oda Kohei, Tabu Kazuaki, Ijuin Sho, Kumagai Kotaro, Fujisaki Kunio, Hashiguchi Masafumi, Inada Yukiko, Uto Hirofumi, Hiramine Yasunari, Kure Takeshi, Hori Takeshi, Taniyama Oki, Kasai Ai, Tamai Tsutomu, Moriuchi Akihiro, Ido Akio
Abstract excerpt
OBJECTIVE: The present study aimed to reveal the factors associated with virologic failure in sofosbuvir and ledipasvir (SOF/LDV)-treated patients, and identify baseline NS5A or NS5B resistance-associated substitutions (RASs). METHODS: Four hundred ninety-three patients with Hepatitis C Virus (HCV) genotype 1b infection were treated with SOF/LDV; 31 had a history of interferon (IFN)-free treatment with...
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