Article
Two-way mixed-effects methods for joint association analysis using both host and pathogen genomes.
Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2018
Wang Miaoyan, Roux Fabrice, Bartoli Claudia, Huard-Chauveau Carine, Meyer Christopher, Lee Hana, Roby Dominique, McPeek Mary Sara, Bergelson Joy
Abstract excerpt
Infectious diseases are often affected by specific pairings of hosts and pathogens and therefore by both of their genomes. The integration of a pair of genomes into genome-wide association mapping can provide an exquisitely detailed view of the genetic landscape of complex traits. We present a statistical method, ATOMM (Analysis with a Two-Organism Mixed Model), that maps a trait of interest to a pair of genomes...
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