Article
Clustered intergenic region sequences as predictors of factor H Binding Protein expression patterns and for assessing Neisseria meningitidis strain coverage by meningococcal vaccines.
PloS one - 1 Jan 2018
Cayrou Caroline, Akinduko Ayodeji A, Mirkes Evgeny M, Lucidarme Jay, Clark Stephen A, Green Luke R, Cooper Helen J, Morrissey Julie, Borrow Ray, Bayliss Christopher D
Abstract excerpt
Factor H binding protein (fHbp) is a major protective antigen in 4C-MenB (Bexsero®) and Trumenba®, two serogroup B meningococcal vaccines, wherein expression level is a determinant of protection. Examination of promoter-containing intergenic region (IGR) sequences indicated that nine fHbp IGR alleles covered 92% of 1,032 invasive meningococcal strains with variant 1 fHbp alleles. Relative expression values for...
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