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Recommendations To Address the Difficulties Encountered When Determining Linezolid Resistance from Whole-Genome Sequencing Data.

Antimicrobial agents and chemotherapy - 1 Aug 2018

Beukers Alicia G, Hasman Henrik, Hegstad Kristin, van Hal Sebastiaan J

Abstract excerpt

Mutations associated with linezolid resistance within the V domain of 23S rRNA are annotated using an Escherichia coli numbering system. The 23S rRNA gene varies in length, nucleotide sequence, and copy number among bacterial species. Consequently, this numbering system is not intuitive and can lead to confusion when mutation sites are being located using whole-genome sequencing data. Using the mutation G2576T as...

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Identifiers

PMID: 29844046
DOI: 10.1128/AAC.00613-18
PMCID: PMC6105777

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