Article
Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2.
Developmental cell - 4 Jun 2018
Zhang Yan M, Zimmer Milena A, Guardia Talia, Callahan Scott J, Mondal Chandrani, Di Martino Julie, Takagi Toshimitsu, Fennell Myles, Garippa Ralph, Campbell Nathaniel R, Bravo-Cordero Jose Javier, White Richard M
Abstract excerpt
Patterning of vertebrate melanophores is essential for mate selection and protection from UV-induced damage. Patterning can be influenced by circulating long-range factors, such as hormones, but it is unclear how their activity is controlled in recipient cells to prevent excesses in cell number and migration. The zebrafish wanderlust mutant harbors a mutation in the sheddase bace2 and exhibits hyperdendritic and...
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